- Desmoglein-1 (DSG1) Antibody
- MyBioSource.com
- Pricing InfoSupplier PageView Company Product Page
- MBS439912
- 0.02 mg (With BSA & Azide at 0.2mg/ml)
- Monoclonal
- Human. Others not known
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
- Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)
- Mouse
- 150kDa (precursor); 160kDa (mature)
- Desmoglein-1 (DSG1)
- desmoglein 1
- PPKS1, SPPK1, EPKHIA, CDHF4, DG1, DSG, EPKHE
- Unconjugated
- IgG1 kappa
- 18D4
Specifications/Features
Recognizes a protein of ~150kDa, identified as Desmoglein-1 (DSG1). Desmoglein-1 is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity